Architecture

EOSC-ENTRUST is creating a common European reference architecture to enable secure connectivity and interoperability between Trusted Research Environments (TREs) across Europe. This initiative ensures that researchers can access and analyse sensitive data in a secure, compliant and federated manner.

Project timeline

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May
Requirements and Capabilities Workshop
June
Roadmap for Blueprint
September
Evaluation and Adoption Workshop
January
EOSC-ENTRUST Blueprint and Interoperability Framework

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Requirements & Capabilities Workshop

May

Each year, the project holds a Requirements and capabilities workshop, where project partners discuss the status of the project roadmap and challenges involved in developing the common TRE Blueprint.

From 6 to 7 May 2025, the project held its second Requirements and capabilities workshop, bringing together stakeholders, TRE providers and technical experts to:

  • Discuss the current status of the project roadmap
  • Gather updated expectations from providers and drivers, especially in relation to interoperability
  • Identify common challenges that could hinder progress towards interoperability within the Blueprint

The workshop slides are available on Zenodo.

Roadmap for Blueprint

June

After the workshop, project partners updated the Roadmap for EOSC-ENTRUST Blueprint, which outlines the steps required to develop a common Blueprint and Interoperability Framework.

The first roadmap establishes a structured three-phase approach for building a federated data access and analysis framework that supports secure cross-border research:

  • Phase 1 (2024): Identification of Blueprint requirements and mapping existing TRE capabilities
  • Phase 2 (2025): Development and validation of key components, including security protocols and interoperability solutions
  • Phase 3 (2026): Finalisation and adoption of the Blueprint across European TRE networks

The updated roadmap confirms that the project is on track with the Blueprint development. It also describes the alignment with EOSC, EHDS and other initiatives such as GDI.

The updated roadmap is now available on Zenodo.

Evaluation and Adoption Workshop

September

In the Evaluation and adoption workshop, the project partners align work across different work packages. The discussions from the workshop help inform adjustments to the Blueprint and training package.

From 17 to 18 September 2025, the project held its second Evaluation and adoption workshop, bringing together project partners to discuss:

  • The TRE inventory and TRE catalogue
  • Driver requirements and TRE capability mapping
  • Adjustments to the Blueprint
The workshop slides are available on Zenodo.

EOSC-ENTRUST Blueprint & Interoperability Framework

January

The EOSC-ENTRUST Blueprint defines the foundational architecture, interoperability framework and security model that TREs should follow. By establishing a harmonised approach to data governance, access and analysis, the Blueprint ensures that TREs across different institutions and countries can effectively work together.

The second version of the EOSC-ENTRUST Blueprint and Interoperability Framework presents updated architecture and operational, legal and technical components to support federated access to sensitive research data across Europe. A key focus of this version is the secure and interoperable processing of sensitive data, with particular emphasis on Authentication, Authorisation and Auditing Infrastructure (AAAI), shared identity management and secure data processing mechanisms.

Read the year two version of the EOSC-ENTRUST Blueprint
Read the Training package for EOSC-ENTRUST year two Blueprint and Interoperability Framework
Read the summary news on the year two EOSC-ENTRUST Blueprint

Driving innovation through TREs

EOSC-ENTRUST is validating its Blueprint through real-world use cases across various domains. In genomics research, it supports the secure federated analysis of human genomic data, ensuring privacy while enabling scientific discovery. For clinical trials, it facilitates the cross-border reuse of clinical research data, promoting collaboration and efficiency in medical studies. In the social sciences, it enables the safe sharing of administrative and social data, fostering responsible data use. It also strengthens public-private collaboration by enhancing industry partnerships within secure data environments.

These pilot projects collectively ensure that the EOSC-ENTRUST framework effectively meets the needs of researchers, data providers and policymakers.

What’s next?

EOSC-ENTRUST is evolving through collaborative input and ongoing technical development. Please get in touch if you don’t want to miss out on our latest progress and upcoming events. Contact us.